The Poison Spider is an enemy encountered in Zombotron 2 (game) and Zombotron 2: Time Machine. It is a Spider that has a container of poison that it shoots from the opening on top of it. This poison ball explodes on impact and is very deadly, making it one of the most dangerous spiders to face. It is unknown if it is a natural creation or if it was bioengineered.
Like other spiders, automatic weapons such as the Mac-11 or AK-47 and powerful handguns, like the Desert Eagle and .357 Magnum work the best. Shooting the green bulge on its back immediately causes the Poison Spider to explode, taking out other nearby enemies as well.